Efficient delivery of double-stranded RNA (dsRNA) into plants remains a critical challenge for sustainable agriculture and gene-silencing technologies. In this study, we uncovered the pivotal role of root hairs as biological gateways for the uptake of dsRNA-laden nanoparticles, demonstrating that nanoparticle internalization into root cells is strongly mediated by hair density and structure.

Using advanced microscopy and physiological manipulation, we showed that enhancing root hair development significantly increases nanoparticle entry and systemic distribution, while suppression of hair growth prevents uptake. This mechanistic insight opens new pathways for improving RNA-based crop protection and precision delivery systems in plant biotechnology.

Students: Ido Simon, Itamar Ziv
Collaborators: Aviram Avital, Avi Schroeder